Pii: S0304-3940(00)01152-6
نویسندگان
چکیده
Striatal glutamate release during novelty exposure-induced hyperactivity was studied by microdialysis in freelymoving olfactory bulbectomized (OBX) rats. After collecting three 10 min basal striatal dialysate samples, the animals were transferred to an open-®eld apparatus (novelty) and locomotor activity recorded for 60 min. OBX rats showed signi®cantly more locomotor activity (1210 ^ 270 cm) than sham-operated rats (420 ^ 70 cm), but only in the ®rst 10 min after exposure to the novel environment. During the same period, striatal glutamate levels increased to 163 ^ 21% of the basal value in OBX rats, while no changes were seen in the striatum of sham-operated controls. These ®ndings suggest that olfactory bulbectomy results in an increased response of the striatal glutamatergic system to novelty stress, and may consequently cause hyperactivity. q 2000 Elsevier Science Ireland Ltd. All rights reserved.
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